The liver filters the blood coming from the digestive tract before passing it to the rest of the body. It also detoxifies chemicals and metabolizes substances like CBD. It is only natural, therefore, that some people wonder if the CBD in their Hemp Oil may affect liver function.
The World Health Organization has stated in its 2018 critical review report that CBD is generally well-tolerated by the human body and non-addictive. However, a 2019 University of Arkansas study on mice warned that large doses of CBD could cause liver damage and elevated liver enzymes.
The study triggered a flurry of research. Critics immediately pointed out a number of problems with the study, including the huge amounts of CBD administered to the mice. Thankfully, further studies suggest that healthy consumers following the general guidelines of CBD consumption don’t have to worry about liver damage.
How Is CBD Metabolized in the Liver?
When we ingest CBD, it passes through our stomach and is then directed towards our liver. It is metabolized there and broken down by liver enzymes before entering our bloodstream.
The enzymes involved in breaking down CBD are called CYP450. The same enzymes are responsible for metabolizing more than 60% of prescription medication. This means that the liver has to metabolize both CBD and any other medicine at the same time. So, how does it choose which one to prioritize?
How Does CBD Interact with the Liver and Other Medication?
CBD and other medications are broken down by the same CYP450 enzymes. However, CBD seems to reach the liver first, thus out-competing the other medication. According to research, CBD’s metabolism appears to inhibit CYP450 from metabolizing some common pharmaceutical drugs like some antidepressants, anti-epileptics, blood thinners, and antihistamines.
While the liver metabolizes CBD, it can’t metabolize any other medication in the body. This leads to higher concentrations than normal and can result in adverse side effects.
This is why doctors and physicians are being cautious when patients take CBD alongside other medications. They are concerned that the interaction between CBD and other medications could cause health problems.
When the other medication cannot be properly metabolized, it lingers in the body longer, often accumulating in fatty tissue located in the liver. This causes liver damage over time.
What Did the Arkansas University Study Find?
Just like other natural or chemical compounds, CBD can be toxic when taken in huge quantities. The same is true of Ibuprofen, paracetamol, aspirin, and even water.
To study how CBD can affect the liver, the University of Arkansas researchers administered single doses of 246, 738, and 2,460 mg/kg of CBD to mice. The mice that took the maximum dose of 2,460mg/kg displayed liver toxicity, swelling, and damage as well as elevated liver enzyme levels (AST and ALT).
The study also found that doses of over 50mg/kg were toxic when repetitively delivered, even though they were well tolerated when administered once.
So, how high were these doses? The FDA has not issued yet a recommended daily dosage for CBD. FSA, the British equivalent of the FDA, recommends a top dose of 70 mg a day. A quick Internet search shows that people often consume over twice as much.
Even so, the high dose administered by the University of Arkansas researchers was 2,460 mg per kilo: an 80-kg human would have to consume 191,000 mg of pure CBD to get the same dose—or drink almost 4 liters of 5% CBD oil in a single dose.
This is not an everyday scenario, even though this study provides us with valuable insight into what happens when CBD is consumed in huge quantities.
So, what is the typical consumption pattern displayed by CBD consumers?
What Is an Average CBD Dosage?
The average CBD dosage varies immensely depending on the age, metabolism, weight, general condition, and even exercise levels of each person.
For instance, younger people have a quicker metabolism, which means that CBD goes in and out fast. Older people have slower metabolism: they require smaller doses of CBD. Likewise, people who exercise a lot need more CBD because their metabolism is faster. More sedentary people could take less.
The best advice is for people to start with a low dosage of about 5 mg to 10 mg per day and increase it gradually over several days until they reach their desired goal.
How to Manage CBD and Other Medication
It is important to talk to your physician before taking CBD. Your doctor will guide you and help you determine the right dosage as well as advise you regarding any contraindications or drug interactions that might occur. Remember that even over-the-counter medication can interact with CBD.
It is usually suggested to take your CBD when you are not taking any other medication. This way, you give time to your liver to metabolize the medication and the CBD separately. You can space these over the day, taking them a few hours apart to lessen the burden on your liver.
If you are concerned about your liver and CBD, you can also choose to take smaller CBD doses throughout the day. This method is called micro-dosing and lets your liver metabolize smaller quantities of CBD at a time.
Other Ways to Take Your CBD
If you are still concerned about the impact of CBD on your liver, we suggest you choose a topical CBD product.
Here at Synchronicity, we offer a wide range of topical Full-Spectrum Hemp Oil products such as face creams and serums, body oils and body butters, body lotions, and sunscreen. When CBD is applied to your skin, only a tiny quantity may reach the liver. Therefore, you don’t risk burdening your liver and elevating your liver enzymes while still getting all the wholesome benefits of Hemp through your skin.
Synchronicity Full-Spectrum Hemp Oil
Here at Synchronicity, we pride ourselves on setting the standards in the Hemp manufacturing industry.
We have developed CBDRx18, our proprietary Hemp plant, and we know exactly how we grow and harvest it. Our Hemp grows locally in Colorado using sustainable practices. Our products are only made from pure and potent American Hemp.
We test our Full-Spectrum Hemp Oil products not just at the end but throughout the entire manufacturing process. We are sure about the safety and purity of our products and so can you. If you’re in doubt, just check the Certificate of Analysis online using nothing but the product lot number.
To maximize the benefits, we have developed our patented LipidTrans™ infusion process, whereby we infuse whole-plant Hemp in coconut oil or MCT and gently hand-press it. By avoiding harsh chemical extraction methods, our products have no harmful chemicals and solvents that can overload the liver. The fewer chemicals you put in your body, the healthier and happier it will be.
Because we care deeply about you and your needs, we have developed several product ranges with different CBD strengths so that you can choose the one that suits you best.
We are certain that our customers will find the Hemp Oil product that will improve their quality of life. See our Full-Spectrum Hemp Oil products online or try out our trial kit to decide which ones work best for you. We offer free shipping on all orders.
Feel the Full Effect™ with Synchronicity and enjoy the purest Hemp Oil.